Identification of three additional members of rat protein kinase C family: gd‐, ϵ‐ and ξ‐subspecies
Open Access
- 21 December 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 226 (1) , 125-128
- https://doi.org/10.1016/0014-5793(87)80564-1
Abstract
Three types of cDNA clone of the protein kinase C family termed δ, ϵ and ξ were newly identified by molecular cloning and sequence analysis. These members have a common structure that is closely related to, but clearly different from the other four known members of the family which have α‐, βI‐, βII‐ and γ‐sequences, although the ξ‐cDNA available at present does not contain a complete reading frame for a protein kinase C molecule. The diverse heterogeneity of the enzyme seems to be an important factor in determining the mode of response of many tissues and cell types to a variety of external stimuli.Keywords
This publication has 19 references indexed in Scilit:
- Primary structures of human protein kinase C βI and βII differ only in their C‐terminal sequencesFEBS Letters, 1987
- Phosphorylation of the EGF receptor from A431 epidermoid carcinoma cells by three distinct types of protein kinase CFEBS Letters, 1987
- Identification of the structures of multiple subspecies of protein kinase C expressed in rat brainFEBS Letters, 1987
- Three distinct forms of rat brain protein kinase C: Differential response to unsaturated fatty acidsBiochemical and Biophysical Research Communications, 1987
- Tissue-specific expression of three distinct types of rabbit protein kinase CNature, 1987
- Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling PathwaysScience, 1986
- The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester ReceptorScience, 1986
- Cloning and expression of multiple protein kinase C cDNAsCell, 1986
- Cloning of rat brain protein kinase C complementary DNAFEBS Letters, 1986
- Studies and Perspectives of Protein Kinase CScience, 1986