BLOOD ADRENOCORTICOTROPIN (ACTH) IN CHILDREN WITH RHEUMATIC FEVER*

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Abstract
The concentration of adrenocorticotropic hormone (ACTH) in the circulating blood has been measured in normal human subjects and in individuals with a few disease entities. Paris et al. (1) recently reviewed the literature concerning ACTH in the blood of human subjects, as determined by adrenal ascorbic-acid depletion assay technics. They attribute most of the wide variations reported for ACTH concentration to differences in the blood extraction technics. The oxycellulose extraction method (2) yields results compatible with those found when plasma alone is assayed for its ACTH content (1). Neither of these procedures has sufficient sensitivity to detect the concentration of blood ACTH in most normal human subjects. However, they are capable of detecting the elevated concentrations which occur in patients with certain pathologic conditions.

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